Glutamate is the most abundant neurotransmitter in the vertebrate system, and maintaining the correct levels necessary for normal function depends on the interaction of nerve (neuron) and glial cells (astrocytes). Glutamate plays a role in synapse plasticity, and thus in the brain glutamate is important in learning and memory processes.
In a synapse, pre- and post- synaptic cells uptake excess glutamate…but the majority is apparently stored by glial cells. Glutamate/glutamine cycle converts the neurotransmitter to a neurally inactive state.
Abnormal levels of glutamate contribute to a variety of neuological disorders according to studies, for example epilepsy, alzheimers, or hepatic encephalopathy.
Acupoint Zu San Li St-36 influences the metabolic pathway of D-Glutamine and D-Glutamate, according to a research study recently published.